Speaking to TV Guide, Pompeo explained that the friendship should make the audience warm to April (Sarah Drew).
"Meredith will accept April in order to get the audience to accept her," she said, explaining that April and Jackson (Jesse Williams) will move into Meredith's home.
Pompeo also revealed that she wants Meredith and Cristina (Sandra Oh) to become mentors to the new doctors.
"I feel like Meredith and Cristina are much further along in their careers than April and Jackson," she said. "The audience hasn't seen them go through as much training as they've seen us go through. I would love there to be a teaching element as opposed to them being our contemporaries."
Meanwhile, executive producer Shonda Rhimes revealed that she has no plans to introduce any more series regulars, saying: "We're full up."
Grey's Anatomy returns on September 23 on ABC.
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